Sandra Bullock

Scarlet Overkill (voice)

Jon Hamm

Herb Overkill (voice)

Michael Keaton

Walter Nelson (voice)

Allison Janney

Madge Nelson (voice)

Steve Coogan

Professor Flux / Tower Guard (voice)

Jennifer Saunders

The Queen (voice)

Geoffrey Rush

Narrator (voice)

Steve Carell

Young Gru (voice)

Pierre Coffin

Minions (voice)

Katy Mixon

Tina (voice)

Michael Beattie

VNC Announcer / Walter Jr. (voice)

Hiroyuki Sanada

Sumo Villain (voice)